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Steroid therapy ought to be reserved for sickest COVID-19 sufferers, say scientists

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Washington: Most adults with moderate-to-severe COVID-19 have a suppressed immune response towards the novel coronavirus fairly than life-threatening hyper-inflammation, in accordance with a research which suggests steroids resembling dexamethasone ought to be reserved for the sickest sufferers.

Scientists, together with these from St. Jude Children’s Research Hospital within the US, assessed the degrees of the immune system protein cytokines, and different well being markers in 168 adults with COVID-19, 26 adults with flu and 16 wholesome volunteers.

They stated greater than 90 per cent of the COVID-19 sufferers have been hospitalised, and about half within the intensive care unit (ICU), whereas greater than half of flu sufferers have been admitted for therapy, and 35 per cent have been within the ICU.

According to the analysis, revealed within the journal Science Advances, fewer than 5 per cent of the COVID-19 sufferers, together with a number of the sickest people, had the life-threatening, hyperinflammatory immune response often called the cytokine storm syndrome.

The researchers defined that cytokine storms develop when extra or abnormally regulated ranges of cytokine proteins within the physique result in hyperinflammation and tissue harm.

While dexamethasone and different steroids are prescribed to deal with cytokine storms, they stated these medicine can backfire in sufferers whose immune response is already suppressed.

“We did identify a subset of COVID-19 patients with the broadly upregulated array of cytokines. But, overall, the average person with COVID-19 had less inflammation than the average person with flu,” stated research co-author Paul Thomas from St. Jude Children’s Research Hospital.

Based on the findings, the scientists stated therapy suppressing irritation would possibly solely be efficient in a minority of sufferers with the hyperinflammatory profile.

They consider the necessity of the hour is a quick, dependable, and cheap take a look at to measure cytokines and determine sufferers who’re more than likely to profit from dexamethasone therapy.

“Directing immunosuppressive therapies to the small subset of COVID-19 patients who have an overactive immune response is the only way to know if these approaches are ultimately helpful,” stated Philip Mudd, one other co-author of the research from the Washington University School of Medicine within the US.




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